WebN 6-methyladenosine (m 6 A) modification controls cell fate determination. Here, we show that liquid-liquid phase separation (LLPS) of YTH N 6-methyladenosine RNA binding protein 1 (YTHDF1), a pivotal m 6 A “reader” protein, promotes the transdifferentiation of spermatogonial stem cells (SSCs) into neural stem cell-like cells by activating the IκB … WebDec 3, 2024 · The liquid–liquid phase separation (LLPS) of proteins has been found ubiquitously in eukaryotic cells, and is critical in the control of many biological processes by forming a temporary condensed phase with different bimolecular components. TDP-43 is recruited to stress granules in cells and is the main component of TDP-43 granules and …
Protein phase separation and its role in chromatin organization …
WebApr 1, 2024 · In this review article, some fundamental aspects and recent progress of biomolecular LLPS in living cells and test tubes are introduced and applications of … WebQuantitative analysis of protein liquid-liquid phase separation Author: Qi, Runzhang ORCID: 0000-0002-7805-6501 Awarding Body: University of Cambridge Current Institution: University of Cambridge Date of Award: 2024 Availability of Full Text: Access from EThOS ... atto jobs
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WebRas GTPase-activating protein-binding protein 1 (G3BP1) is the key protein driving the formation of cytoplasmic stress granules (SGs) by liquid-liquid phase separation (LLPS). … WebApr 2, 2024 · The interspersion of hydrophilic and hydrophobic residues and a lack of secondary structure formation result in a frustrated microphase separation, which explains both the strong correlation between ELP condensate stability and interfacial hydrophobicity scales, as well as the prevalence of protein-water hydrogen bonds. The phase … WebThe sequence features which reflect the LLPS behavior are also available for other human protein candidates. The online database provides a convenient interface for the research community to easily browse, search and download phase separation associated proteins. atto japanese