Asebia mice
WebOverall VAS of pruritus correlated positively with age in both males (Pearson r=0.2540, p <0.0001) and females (Pearson r=0.2141, p <0.0001). Because pruritus can be associated with epidermal function, which declines after age 50 years, next we analyzed the prevalence and VAS of pruritus in patients aged ≤50 vs compared to those >50 years old. Web1 nov 2001 · The mutant ''asebia'' mouse exhibits hair loss and scarring alopecia associated with markedly hypoplastic sebaceous glands ( Stenn, 2001 ). Data reported …
Asebia mice
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Web9 mar 2015 · With the identification of Scd1 gene mutations as the genetic basis of the asebia phenotype and with the advent of more refined methods for manipulating the mouse genome, asebia mice progressively lost importance. However, they contributed to, or even provided the initial spark for, several current research topics. Web12 gen 2016 · There is increasing evidence and growing consensus that Psoriasis, Psoriatic arthritis and associated co-morbidity are best considered under the umbrella of the “psoriatic disease” concept [2, 3].This unifying view is based on the overlap in clinical symptoms, the common genetic susceptibility factors, the shared successes in targeted …
WebThe most obvious initial application of asebia mice was the analysis of skin lipids, and ab skin was shown to be deficient in esterified sterol and waxes, but overproportionally … WebWe demonstrated that asebia mice have constitutively elevated intercellular adhesion molecule-1 (ICAM-1) mRNA expression, which is not detectable in the wild type, and that dermal mast cell numbers were 3.1-fold higher than the wild type (P < 0.001). We utilized this model to explore the anti-inflammatory effects of cyclosporin A (CsA).
Web9 mar 2015 · First described as an alopecic spontaneous mutant mouse line lacking sebaceous glands in a publication in Science in 1965 by Allen H. Gates and Marvin …
WebAsebia mice of both sexes demonstrated significantly greater total and resting oxygen consumption (surrogates for total and basal metabolic rate) than littermate controls . ob/ob mice are known to be markedly hypometabolic, since in the absence of leptin, they exist in a state of perceived starvation and actively conserve energy.
Web1 mar 2014 · Introduction. The skin is a large and complex organ that is very heterogeneous in terms of cells of mesenchymal and epithelial origin. In this special issue of the BBA — Molecular and Cell Biology of Lipids we are focusing on lipid metabolism in the epidermis, particularly as it relates to the permeability and antimicrobial barrier functions of the skin. dr taiwo oluyemoWebFigure 4 Asebia J1 SC displays a significant reduction in nonpolar lipid fractions.Panel A: Full-thickness mouse skin was excised from shaved asebia J1 (n=4) and wild-type (n=6) … dr tai winter haven flWebSummary. We compared the skin of the mutant mouse asebia (ab/ab) with that of normal BALB/c mice by examining dermal cell counts, epidermal thickness, epidermal colour bands readingWeb16 feb 2015 · We demonstrated that asebia mice have constitutively elevated intercellular adhesion molecule-1 (ICAM-1) mRNA expression, which is not detectable in the wild … colour banding hairWeb1 mag 2003 · Dermatology Services, Veterans Administration Medical Center, and Department of Dermatology University of California, San Francisco, California, USA. The Journal of Investigative Dermatology , 01 May 2003, 120 (5): 728-737. colour bass vol 3WebThe most obvious initial application of asebia mice was the analysis of skin lipids, and ab skin was shown to be deficient in esterified sterol and waxes, but overproportionally rich in free sterols, suggesting a fundamental defect in fatty acid metabolism in the epidermis (7). In addition, asebia mice were later employed dr. taiwo stanfordWebAsebia J1 mice showed normal permeability barrier homeostasis and extracellular lamellar membrane structures, but they displayed epidermal hyperplasia, inflammation, and … dr tai winter haven florida